January 6th, 2011 
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High cholesterol levels in circulating IC, surrogate markers of modified LDL, are associated with increased carotid IMT and cardiovascular events in type 1 diabetes. Different modifications of LDL are involved in IC formation, but which are predictive of vascular events is not known. Therefore, we measured oxLDL, AGE-LDL and MDA-LDL in IC and determined their relationship with increased carotid IMT and compared the strength of the association to that observed with conventional risk factors.
Levels of oxLDL, AGE-LDL and MDA-LDL were measured in circulating IC isolated from sera of 479 patients of the DCCT/EDIC cohort, collected at baseline. Internal and common carotid IMT were measured 8 and 14 years later by DCCT/EDIC.
OxLDL, AGE-LDL and MDA-LDL levels in circulating IC were significantly correlated with diabetes duration, BMI, lipid and blood pressure, but not with age. Multivariate logistic regression models indicated that individuals in the highest versus lowest quartile of oxLDL and AGE-LDL in IC had a 6.11-fold (CI: 2.51-14.8) and a 6.4-fold (CI: 2.53-16.2) increase in the odds of having high carotid IMT, respectively, after adjusting for conventional risk factors. Parallel analyses resulted in odds ratios of 2.62 (CI:1.24, 5.55) for LDL-C; 1.45 (CI:0.69, 3.03) for diastolic blood pressure and 2.33 (CI:1.09, 4.99) for HbA1c.
OxLDL and AGE-LDL in circulating IC were significantly associated with progression and increased levels of carotid IMT in type 1 diabetes.
Diabetes Journal publish ahead of print articles
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