Posts Tagged ‘Study’

Isis Initiates Phase 1 Study Of ISIS-PTP1BRx To Treat Type 2 Diabetes

Isis Pharmaceuticals, Inc. (NASDAQ: ISIS) announced that it has initiated a Phase 1 clinical study for ISIS-PTP1BRx, an antisense drug for the treatment of type 2 diabetes targeting protein tyrosine phosphatase-1B, PTP-1B. ISIS-PTP1BRx is designed to increase the body’s sensitivity to the natural hormone insulin, resulting in better glucose control for patients with type 2 diabetes…
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Dog Consumed Part Of A Sleeping Patient’s Toe: Case Study To Highlight The Danger Of Pets In The Presence Of Open Wounds

In a case study that illustrates the need for people with diabetes to be cautious of foot injuries and to protect themselves from pets, a woman with numbness in her feet caused by diabetic neuropathy slept through a traumatic episode in which her Jack Russell terrier chewed off part of her slightly infected big toe, according to an article published in this month’s issue of the…
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?Knocking Socks Off? Saves Limbs and Lives, New Diabetes Study Shows

“Knocking Socks Off” Saves Limbs and Lives, New Diabetes Study Shows











For more information on “Knock Your Socks Off!”, visit www.apma.org/diabetes.


Bethesda, MD (Vocus) November 17, 2010

The number of Americans diagnosed with diabetes continues to rise toward record levels, with an estimated one in three adults predicted to have the disease by the year 2050 according to the Centers for Disease Control. Because many serious complications from diabetes present in the lower limbs, proper foot care for those with the disease is a vital step to keeping the disease in check. In fact, a new study on foot care for people with diabetes conducted by Thomson Reuters confirms that care by a podiatrist can drastically reduce the incidence of diabetes-related hospitalizations and amputations.

“During November’s Diabetes Awareness Month, it’s important to realize that simple lifestyle changes can go a long way toward staying healthy with diabetes. These include eating right, being active, monitoring blood glucose, and checking your feet daily,” said Dr. Kathleen Stone, president of the American Podiatric Medical Association (APMA). “Diabetic foot complications are the leading cause of non-traumatic, lower-limb amputation in the U.S. Remembering to ‘knock your socks off’ at every doctor’s visit will help to catch any potential lower limb complications early.”

According to preliminary results from the Thomson Reuters study, those with diabetes who received care from a podiatrist had a nearly 29 percent lower risk of lower limb amputation, and 24 percent lower risk of hospitalization, than those who did not. APMA’s “Knock Your Socks Off” campaign, running during Diabetes Awareness Month, aims to encourage everyone with diabetes and those at risk for the disease to remove their shoes and socks and inspect their feet and visit a podiatrist for a foot exam.

Feet should be checked regularly for signs and symptoms of diabetes to help prevent serious complications. Symptoms in the feet such as redness, tingling and cuts that are not healing can lead to diabetic ulcers and even possible amputation without prompt medical care.

“The Thomson Reuters study results show that just one visit to a podiatrist can drastically reduce the chance of a tragic diabetes-related amputation. There is now no question that a podiatrist must be a part of everyone’s diabetes management team,” Dr. Stone said. The APMA-sponsored study was conducted using Thomson Reuters’ MarketScan Research Databases, which house fully integrated, de-identified health-care claims data extensively used by researchers to understand health economics and outcomes. Studies based on MarketScan data have been published in more than 130 peer-reviewed articles in the past five years.

For more information on the Thomson Reuters study, click here. To learn more about how diabetes affects the feet and to find a podiatrist near you, visit APMA’s “Knock Your Socks Off” diabetes resource page at http://www.apma.org/diabetes .

“Like” APMA on Facebook: http://www.facebook.com/theAPMA

Follow us on Twitter: @APMAtweets

Vote for your favorite “Knock Your Socks Off” video!: http://knockyoursocksoff.strutta.com

Founded in 1912, the American Podiatric Medical Association (APMA) is the nation’s leading and recognized professional organization for doctors of podiatric medicine (DPMs). DPMs are podiatric physicians and surgeons, also known as podiatrists, qualified by their education, training and experience to diagnose and treat conditions affecting the foot, ankle and structures of the leg. The medical education and training of a DPM includes four years of undergraduate education, four years of graduate education at an accredited podiatric medical college and two or three years of hospital residency training. APMA has 53 state component locations across the United States and its territories, with a membership of close to 12,000 podiatrists. All practicing APMA members are licensed by the state in which they practice podiatric medicine. For more information, visit http://www.apma.org .

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Long-Term Study Of Remote Community Finds Almost No Cancer Or Diabetes In Individuals With Genetically Low Growth Hormone Activity

A 22-year study of abnormally short individuals suggests that growth-stunting mutations also may stunt two of humanity’s worst diseases. Published in Science Translational Medicine, part of the Science family of journals, the study raises the prospect of achieving similar protection in full-grown adults by other means, such as pharmaceuticals or controlled diets…
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Study On Effects Of Resveratrol And Quercetin On Inflammation And Insulin Resistance

A study was carried out to examine the extent to which quercetin and trans-resveratrol (RSV) prevented inflammation or insulin resistance in primary cultures of human adipocytes treated with tumor necrosis factor-a (TNF-a) – an inflammatory cytokine elevated in the plasma and adipose tissue of obese, diabetic individuals…
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STUDY SHOWS THAT DIABETES MANAGEMENT IS A HOT TOPIC — A Recent Study of 30,000 Members shows that 36% are researching Diabetes Management Help

Sarasota, FL (PRWEB) November 3, 2003 -

– Anosos, a leading health and wellness company, profiled 30,000 of its members in October to find out how many people are interested in learning about diabetes. Results from the study revealed that approximately 36% of the profiled members came to Anosos in the last year looking for diabetes help. Of those members interested in learning about diabetes, 28% are looking for diet and nutrition information while 10% are searching for diabetes signs, symptoms and self-screening diagnostic methods. The results from this member study solidified Anosos’ premise that diabetes is a prominent healthcare problem in today’s society of fast food and convenience, which unfortunately dominates the lifestyle choices of the majority. Furthermore, the study shows that people who think that they are at risk for diabetes are actively seeking educational material in conjunction with medically sound diabetes management solutions.

“Many of our members [diabetics] are looking for diet plans that incorporate real foods,” said Dr. Kim Gibson, Chief Medical Officer for Anosos, who has dealt with diabetics for many years in solo-practice. “Our members do not know what a 1500-calorie diet is nor do they know the right foods to eat…they are looking for educational resources that will answer these questions and help them lose weight and lower their blood sugar as well,” reiterated Gibson. Dr. Gibson went on to say that “The Anosos LifePlan [a 12-week weight loss and weight management plan] gives our members the opportunity to learn about their illness and the proper foods they should eat. At Anosos, we hope to change people’s lifestyles through education – and hopefully, make it stick…that is our goal.”

According to the American Diabetes Association, more than 17 million Americans are living with diabetes, and many of them do not even know it. Just over 15% of the population has some form of pre-diabetes, which is a condition that occurs when a person’s blood sugar levels are higher than normal but not high enough for a diagnosis of type 2 diabetes, or adult onset diabetes. Common diabetes signs and symptoms include excess urination, excess thirst, blurred vision, yeast or fungal infections and fatigue. Unfortunately, many people have these symptoms but do not pay any attention to them until diabetic complications arise. Being aware of your body is a key ingredient in preventing diabetes onset and/or stopping the development of complications. If you have any of these symptoms, make an appointment with your physician as soon as possible.

To combat diabetes and help prevent further complications and/or onset, regular exercise and a healthy diet geared towards attaining a normal BMI [Body Mass Index], in addition to lowering blood pressure and cholesterol levels, is prudent. In fact, in a study published in the medical journal Lancet in June 2002, study participants classified with ‘pre-diabetes’ lowered their risk of developing Type 2 Diabetes by 58% through a combination of eating a low-fat low-carb diet and exercising 30 minutes a day. Weight loss through a healthy diet and adequate exercise regimen helps the body properly use insulin, which breaks down blood sugar, or glucose, in the body.

There are several factors that play a significant role in determining your level of risk for diabetes. The risk factors include being overweight, leading a sedentary lifestyle, having high cholesterol or blood pressure, your age and having a relative(s) diagnosed with diabetes. The older you are, the higher your risk for diabetes. If you have any of the symptoms mentioned or fit the profile of ‘high risk’, a good first step is to assess your risk by taking the Anosos HealthCheck, a preliminary health questionnaire that asks medically appropriate questions to determine your risk level. We recommend that you print out the results from the HealthCheck and take it with you to your next physician’s appointment. Use the results as a guide to help you get on the right path to living a healthy lifestyle. For further information about diabetes, visit www.anosos.com/diabetes.

About Anosos: Anosos, a leading health and wellness company, was established in 2001 by a small group of physicians and health care professionals seeking realistic weight loss solutions to combat the ever-rising overweight and obese population, in addition to the slue of medical problems caused by excess weight. Due to the lack of resources available in the medical mainstream, Anosos developed the Anosos LifePlan, a 12-week weight loss and weight management program focused on helping individuals obtain a medically healthy weight through delivering personalized diet and exercise plans. The Anosos LifePlan is based upon the belief that education, motivation and accountability are the strongest drivers of a responsible and safe weight management plan. Subsequently, the company’s three main goals are to teach people about their health, to make health a priority through proper diet, exercise and accountability and to develop and offer medically sound products and services that advocate and promote a healthy lifestyle.

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Contact:

James Williamson

VP, Marketing

w. 941.308.8200

c. 941.586.1347

james@anosos.com

Supporting Graphics:

http://www.anosos.com/Content/CP/Media_Kit.aspx


Note to Editors: Upon request, Dr. Kim Gibson is available for media interviews.



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Association of a fasting glucose genetic risk score with subclinical atherosclerosis: The Atherosclerosis Risk in Communities (ARIC) Study

AbstractObjective:

Elevated fasting glucose level is associated with increased carotid intima-media thickness (IMT), a measure of subclinical atherosclerosis. It is unclear if this association is causal. Using the principal of Mendelian randomization we sought to explore the causal association between circulating glucose and IMT by examining the association of a genetic risk score with IMT.


Research Design and Methods:

The sample was drawn from the ARIC study and included7260 non-diabetic Caucasian individuals with IMT measurements and relevant genotyping. Components of the fasting glucose genetic risk score (FGGRS) were selected from a fasting glucose GWAS in ARIC. The score was created by combining five SNPs (rs780094 [GCKR], rs560887 [G6PC2], rs4607517 [GCK], rs13266634 [SLC30A8], and rs10830963 [MTNR1B]) and weighting each SNP by its strength of association with fasting glucose. IMT was measured through bilateral carotid ultrasound. Mean IMT was regressed on the FGGRS and on the component SNPs, individually.


Results:

The FGGRS was significantly associated (p = .009) with mean IMT The difference in IMT predicted by a 1 SD increment in the FGGRS, (0.0048 mm), was not clinically relevant but was larger than would have been predicted based on observed associations between the FFGRS, fasting glucose, and IMT. Additional adjustment for baseline measured glucose in regression models attenuated the association by about one third.


Conclusions:

The significant association of the fasting glucose genetic risk score with IMT suggests a possible a causal association of elevated fasting glucose with atherosclerosis although it may be that these loci influence IMT through non-glucose pathways.



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