July 26th, 2011 
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Type 2 diabetes and obesity in pregnancy is a daunting duo, according to new research published this month in The Journal of Maternal-Fetal and Neonatal Medicine. The study shows that both conditions independently contribute to higher risks, opening the door to a wide range of pregnancy, delivery and newborn complications…
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July 25th, 2011 admin Circulating levels of soluble receptor for advanced glycation end products (sRAGE) likely comprises both a secreted isoform (esRAGE) and wild-type RAGE cleaved from the cell membrane. Both sRAGE and esRAGE have been proposed as biomarkers of cardiovascular disease (CVD) but prospective data are limited. We examined the relationship of sRAGE and esRAGE to incident coronary heart disease (CHD) and stroke in type 2 diabetic patients followed for 3.9 years in a trial of atorvastatin: the Collaborative Atorvastatin Diabetes Study (CARDS).
We used a nested case control design sampling all incident cases of CVD with available plasma and randomly selecting three control subjects, who were free of CVD throughout follow-up, per case. Analysis was by Cox regression with adjustment for treatment allocation and relevant covariates.
sRAGE and esRAGE were strongly correlated ( = 0.88) and were both higher in those with lower BMI (P < 0.001), higher adiponectin (P < 0.001), lower eGFR (P = 0.009), and white ethnicity (P < 0.001). Both sRAGE and esRAGE were associated with incident CHD events, independently of treatment allocation and the above factors; hazard ratio (HR) = 1.74 (95% CI 1.25–2.41; P = 0.002) for a doubling of the sRAGE level; HR = 1.45 (1.11–1.89; P = 0.006) for a doubling of the esRAGE level. There was no significant association with stroke; HR for sRAGE = 0.66 (0.38–1.14). Atorvastatin, 10 mg daily, did not alter sRAGE.
Higher levels of sRAGE and esRAGE are associated with incident CHD but not stroke in type 2 diabetes.
Posted in Diabetes Signs 
Tags: Advanced, Analysis, Biomarkers, CARDS, Coronary, Diabetes, Disease, Endogenous, Endproducts, from, Glycation, Heart, Patients, Predictive, Receptor, Risk, Secretory, Soluble, Total, Trial, Type 
No Comments » July 9th, 2011 admin H1N1: Who is at risk for severe illness?
Parents should practice, and get others to practice, frequent hand washing and household hygiene.
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Stroke Belt has highest cognitive decline
BIRMINGHAM, Ala., July 6 (UPI) — Residents of the so-called U.S. Stroke Belt have greater incident cognitive impairment than those who do not live in the South, researchers say.
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Cochrane review doesn’t change our advice on salt reduction, AHA
The AHA was responding to a review of scientific literature by The Cochrane Library just published in the American Journal of Hypertension ( click here for more information).
Read more on Food Navigator USA
Merck Serono announces recipients of second Grant for Fertility Innovation
Merck Serono, a division of Merck KGaA, Darmstadt, Germany, today announces the recipients of its second Grant for Fertility Innovation.
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January 18th, 2011 admin High-sugar teen diet ups heart risk later
ATLANTA, Jan. 12 (UPI) — Teenagers who eat a diet high in sugar — mainly due to sweetened drinks — may have a higher risk of heart disease later in life, U.S. researchers suggest.
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Local experts share insight on violence and mental illness
The Arizona shootings have prompted national discussion on whether there are telltale signs that those who suffer from a mental illness are prone, or even likely, to go on a deadly rampage as did Jared Lee Loughner and whether anything can be done to prevent such tragedies.
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December 20th, 2010 admin Elevated fasting glucose level is associated with increased carotid intima-media thickness (IMT), a measure of subclinical atherosclerosis. It is unclear if this association is causal. Using the principal of Mendelian randomization we sought to explore the causal association between circulating glucose and IMT by examining the association of a genetic risk score with IMT.
The sample was drawn from the ARIC study and included7260 non-diabetic Caucasian individuals with IMT measurements and relevant genotyping. Components of the fasting glucose genetic risk score (FGGRS) were selected from a fasting glucose GWAS in ARIC. The score was created by combining five SNPs (rs780094 [GCKR], rs560887 [G6PC2], rs4607517 [GCK], rs13266634 [SLC30A8], and rs10830963 [MTNR1B]) and weighting each SNP by its strength of association with fasting glucose. IMT was measured through bilateral carotid ultrasound. Mean IMT was regressed on the FGGRS and on the component SNPs, individually.
The FGGRS was significantly associated (p = .009) with mean IMT The difference in IMT predicted by a 1 SD increment in the FGGRS, (0.0048 mm), was not clinically relevant but was larger than would have been predicted based on observed associations between the FFGRS, fasting glucose, and IMT. Additional adjustment for baseline measured glucose in regression models attenuated the association by about one third.
The significant association of the fasting glucose genetic risk score with IMT suggests a possible a causal association of elevated fasting glucose with atherosclerosis although it may be that these loci influence IMT through non-glucose pathways.
Posted in Diabetes Signs Tags: ARIC, Association, atherosclerosis, Communities, fasting, Genetic, Glucose, Risk, score, Study, subclinical No Comments » December 8th, 2010 admin Why does a baby born during the winter months have a higher risk of developing bipolar depression, schizophrenia, SAD (seasonal affective disorder) and other neurological disorders compared to one born during the summer? Scientists from Vanderbilt University, USA, wrote in the journal Nature Neuroscience that exactly when a baby is born can have a dramatic and lifelong effect on the functioning of their biological clocks. Professor of Biological Sciences Douglas McMahon, and team say their experiment provides the first proof of seasonal imprinting of biological clocks in mammals…
Posted in Diabetes Signs Tags: Affects, Being, Biological, Born, Clock, Disorder, Influencing, Neurological, Risk, Winter No Comments » December 3rd, 2010 admin Exposure to polluted air early in life led to an accumulation of abdominal fat and insulin resistance in mice even if they ate a normal diet, according to new research. Animals exposed to the fine-particulate air pollution had larger and more fat cells in their abdominal area and higher blood sugar levels than did animals eating the same diet but breathing clean air…
Diabetes News From Medical News Today
November 20th, 2010 admin Childhood obesity linked to increased risk of adult cardiovascular and metabolic disorders
Mounting evidence linking childhood obesity to an increasing risk of obesity, heart disease, type 2 diabetes, and other cardiovascular and metabolic disorders in adulthood is clearly presented in a comprehensive review article.
Read more on Science Daily
Delta Dental Reminder: Regular Dental Checkups Can Help Detect Diabetes and Stave off Periodontal Disease
SAN FRANCISCO–(BUSINESS WIRE)–A group of Delta Dental companies reminds people during American Diabetes Month(R) that regular dental checkups can help in the detection of diabetes and help prevent gum disease.
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Posted in Diabetes Signs Tags: adult, cardiovascular, Childhood, disorders, increased, Linked, metabolic, Obesity, Risk No Comments » November 13th, 2010 admin The symptoms of diabetes – Who is at risk of diabetes?
What is diabetes?
Diabetes is a disorder in the body’s ability to convert glucose into energy. It is caused due to insufficient production of glucose by the pancreas. In diabetes patients, glucose production is reached.
Diabetes symptoms often start slowly, and difficult to recognize at first. They May of fatigue, sudden weight loss, blurred vision, slow healing of wounds, frequent urination – especially at night, and thirst. The loss of fluids persuades extreme thirst, leading to more frequent urination.
Doctor believe a patient to have diabetes if he has health problems related to diabetes such as heart disease, changes in vision, deadness in the feet and legs or sores that are slow to heal. These Diabetes Causes do not indicate that the person has diabetes, but these problems must consult a doctor.
A person with diabetes in May really be free from symptoms. Type 2 diabetes, in particular, develops slowly, even years before it is diagnosed. When symptoms develop, they differ from one person to another.
Develop symptoms ranging from type I and type II diabetes. In type I diabetes, they usually slowly in children or young people over a few days or weeks. In type II diabetes, symptoms develop more slowly over a period of several years – in adults over forty years. Adults do not understand that they have diabetes mellitus.
Type – 1 Diabetes Symptoms:
The symptoms of type 1 diabetes are often abruptly. They include:
1) thirst exception (also called polydipsia)
2) Dry mouth
3) frequent urination (also called polyuria)
4) Weight loss
5) You feel weak and tired
6) The lack of clarity of vision
Type – 2 diabetes symptoms:
People with type 2 diabetes do not usually any symptoms.
They include: – blurred vision
1) Cuts or sores that heal slowly
2) skin itchy
3) increased thirst
4) frequent urination
5) leg pain
Type – 3 diabetes symptoms:
1) increased thirst
2) increased urination
3) weight loss despite good appetite
4) fatigue and weakness
5) nausea and vomiting
6) including those who are frequent infections of the bladder, vagina and skin
Other symptoms of diabetes include:
1) flu-like symptoms – such as a viral illness, with fatigue and loss of appetite.
2) The gain or weight loss – as the body attempts to reward for lost fluids and sugar, you tend to eat more than normal and increased weight. On the other hand, a May also eat more than usual, but also because the fall in the muscle tissues do not get enough glucose to generate growth and energy. In fact, most people with type 1 diabetes are at or below their normal weight.
3) Blurred vision – high levels of sugar in the blood draw fluids from tissues in the body including the eye lenses. For many people, causing mild blurred vision. However, for others the effects May be much more serious and even blindness.
4) Nerve damage (neuropathy) – excess sugar in the blood can lead to loss of sensation in hands and feet. May also supports a burning pain in the legs, feet, arms and hands. Many men over age 50 and older with diabetes May experience some degree of relation dysfunction damage to nerves that can produce an erection.
5) Swelling of the gums and tender – Diabetes problem increases the risk of infection in the gums and bones that enter the teeth in place.
6) Recurrent yeast infections.
7) The smooth dark skin changes of the neck, armpits and groin, called acanthosis nigricans.
Diabetes is sometimes not identified early; because people feel they are normally urinate more, simply because they drink more. It is preferable to self-controlled by a doctor before beginning to limit his fluid intake. If you have any of these symptoms, contact a doctor immediately be verified.
For more information visit Diabetes Symptoms Home remedies
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Dr. Dahlman’s video explains the symptoms of heart disease which can include high blood pressure, high cholesterol and diabetes. Heart disease symptoms may develop if you smoke, are obese or inactive, have a family member with symptoms of heart disease or have a poor diet. Symptoms of heart disease can be eliminated with a healthier diet.
October 29th, 2010 admin Coffee consumption has been inversely associated with type 2 diabetes risk, but its mechanisms are largely unknown. We aimed to examine whether plasma levels of sex hormones and sex hormone-binding globulin (SHBG) may account for the inverse association between coffee consumption and type 2 diabetes risk.
We conducted a case-control study nested in the prospective Women’s Health Study. During a median followup of 10 years, 359 postmenopausal women with newly diagnosed type 2 diabetes were matched with 359 controls by age, race, duration of follow-up, and time of blood draw.
Caffeinated-coffee was positively associated with SHBG but not with sex hormones. Multivariable-adjusted geometric mean levels of SHBG were 26.6 nmol/L among women consuming ≥4 cups/day of caffeinated-coffee and 23.0 nmol/L among non-drinkers (P for trend = 0.01). In contrast, neither decaffeinated-coffee nor tea was associated with SHBG or sex hormones. Multivariable-adjusted odds ratio (OR) of type 2 diabetes for women consuming ≥4 cups/day of caffeinated-coffee compared with non-drinkers was 0.47 (95% CI, 0.23 – 0.94; P for trend = 0.047). The association was largely attenuated after further adjusting for SHBG (OR=0.71; 95% CI, 0.31 – 1.61; P for trend = 0.47). In addition, carriers of rs6259 minor allele and non-carriers of rs6257 minor allele of SHBG gene consuming ≥2 cups/day of caffeinated-coffee had lower risk of type 2 diabetes in directions corresponding to their associated SHBG.
Our findings suggest that SHBG may account for the inverse association between coffee consumption and type 2 diabetes risk among postmenopausal women.
Posted in Diabetes Signs Tags: Caffeine, Coffee, Consumption, Diabetes, Globulin, HormoneBinding, Postmenopausal, Relation, Risk, Type, Women No Comments »
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