Posts Tagged ‘Blood’

Brain GLP-1 Signaling Regulates Femoral Artery Blood Flow and Insulin Sensitivity Through Hypothalamic PKC-{delta}

OBJECTIVE

Glucagon-like peptide 1 (GLP-1) is a gut-brain hormone that regulates food intake, energy metabolism, and cardiovascular functions. In the brain, through a currently unknown molecular mechanism, it simultaneously reduces femoral artery blood flow and muscle glucose uptake. By analogy to pancreatic β-cells where GLP-1 activates protein kinase C (PKC) to stimulate insulin secretion, we postulated that PKC enzymes would be molecular targets of brain GLP-1 signaling that regulate metabolic and vascular function.


RESEARCH DESIGN AND METHODS

We used both genetic and pharmacological approaches to investigate the role of PKC isoforms in brain GLP-1 signaling in the conscious, free-moving mouse simultaneous with metabolic and vascular measurements.


RESULTS

In normal wild-type (WT) mouse brain, the GLP-1 receptor (GLP-1R) agonist exendin-4 selectively promotes translocation of PKC- (but not -βII, -α, or -) to the plasma membrane. This translocation is blocked in Glp1r–/– mice and in WT mice infused in the brain with exendin-9, an antagonist of the GLP-1R. This mechanism coordinates both blood flow in the femoral artery and whole-body insulin sensitivity. Consequently, in hyperglycemic, high-fat diet–fed diabetic mice, hypothalamic PKC- activity was increased and its pharmacological inhibition improved both insulin-sensitive metabolic and vascular phenotypes.


CONCLUSIONS

Our studies show that brain GLP-1 signaling activates hypothalamic glucose-dependent PKC- to regulate femoral artery blood flow and insulin sensitivity. This mechanism is attenuated during the development of experimental hyperglycemia and may contribute to the pathophysiology of type 2 diabetes.

Diabetes Journal publish ahead of print articles

Nanostructure Promotes Growth Of New Blood Vessels, Mimics Natural Protein

Tissue deprived of oxygen (ischemia) is a serious health condition that can lead to damaged heart tissue following a heart attack and, in the case of peripheral arterial disease in limbs, amputation, particularly in diabetic patients…
Diabetes News From Medical News Today

Diabetes Blood Sugar Control – Tonik Herba Gamat

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Medical help please – “Small blood vessel changes in brain (possibly due to diabetes)”?

Question by Jodie: Medical help please – “Small blood vessel changes in brain (possibly due to diabetes)”?
For about a year now my husband has been having really tiny, very infrequent episodes of feeling almost dizzy, where it shifts him to the left. He went to the neuro, who scheduled an MRI, with a return visit in December (busy month).
The nurses said today that the results stated “small blood vessel changes in the brain, no sign of a stroke.”
What does this mean? Is there a name I can look up?
In particular, he is very interested in knowing any possible prognosis. Do people typically get these changes over time? or is a sign of something more sinister? Nurses there won’t answer his questions, and he really doesn’t want to have to wait a month but he is out of town even now.
That’s the short end of the story. If you want to hear his history, keep reading. I don’t know if it’s necessary or not …
History Born 12/57 to a poor family who never took him to doctors. Over the years his symptoms seemed very apparent, but doctors kept dismissing them at annual check-ups, with answers like, “You need to get off your feet.” Finally, about 5 years ago, he went to an urgent care with palpatations, where the suspicious doctor ran the appropriate tests and confirmed diabetes. Eventually ended up on the pump.
Since then, he was been diagnosed with neuropathy in his arms and legs, retinopathy, high blood pressure (under control now), and essential tremors (taking meds, not under control). He exercises incessantly and basically lives off Slim Fast and a sensible dinner.
Let me know if I need to answer any questions. I’ll be around all day, looking for comments. Thanks!
The essential tremors are not related to blood sugar. He has his blood pressure and diabetes under control. His last 90-day check-up came back as “5,” which is better than mine. (I’m healthy and 6 .)
How can he find out if the problem in the brain is serious or not? Who else can he talk to? His neuro just doesn’t seem to take him seriously. The nurse basically said there is no treatment. The neuro only took the MRI at my husband’s insistance.
Also, he exercises for about 2 hours every day, rain or shine.
Husband asking – No signs of having a stroke showed up on MRI. Would a past TIA show up as “small blood vessel changes”?

Best answer:

Answer by matador 89
Jennifer W,

Thank you for the history. There are so many causes for “small blood vessel changes in the brain” that range from serious to not so serious. Basically, alterations to the small blood vessels of the brain indicate possibilities of lesions in the subcortical structures and might lead to malfunction of any or all of the senses. These changes may be caused by hypertension – which is also known as the ‘silent killer’ because it so often has no symptoms until too late – and may indicate that this condition has been present for some time. These small blood vessel changes may also indicate lacunar infarcts which are small infarcts in the deeper parts of the brain (basal ganglia, thalamus, white matter) and in the brain stem. MRI is the scan of choice to observe these and notice if there has been any significant change to the brain structure. Most of his symptoms are often associated with diabetes. Hypoglycaemia is often the cause for tremors, and usually the tremors resolve once blood sugars are raised. However you need to discuss this with your doctor as other factors may be involved. It would appear that care needs to exercised in keeping the blood glucose/sugar steady as this is the best way to decrease the severity of diabetic neuropathies, which, unfortunately, are not reversible or curable. Likewise the blood pressure, being under medical control, should be stable. The mechanisms of diabetic neuropathy are not well understood. Pain relief medication may help and can control some associated symptoms, but the process is generally progressive. He will likely understand about exercise and diabetes and will no doubt carry out his exercise accordingly. I would expect that his forthcoming appointment in December will encompass more examinations. If there are any questions that are required to be answered, might I suggest that you have them written down on paper. Very often some questions are forgotten at the consultation and only remembered after it is over. I wish him well.

ALL ANSWERS SHOULD BE THOROUGHLY RESEARCHED, IN ANY FORUM AND ESPECIALLY IN THIS ONE. – MANY ANSWERS ARE FLAWED.

It is extremely important to obtain an accurate diagnosis before trying to find a cure. Many diseases and conditions share common symptoms.

The information provided here should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions.

Hope this helps
matador 89

Add your own answer in the comments!

Fasting-Induced Protein Phosphatase 1 Regulatory Subunit Contributes to Postprandial Blood Glucose Homeostasis via Regulation on Hepatic Glycogenesis

OBJECTIVE

Most animals experience fasting–feeding cycles throughout their lives. It is well known that the liver plays a central role in regulating glycogen metabolism. However, how hepatic glycogenesis is coordinated with the fasting–feeding cycle to control postprandial glucose homeostasis remains largely unknown. This study determines the molecular mechanism underlying the coupling of hepatic glycogenesis with the fasting–feeding cycle.


RESEARCH DESIGN AND METHODS

Through a series of molecular, cellular, and animal studies, we investigated how PPP1R3G, a glycogen-targeting regulatory subunit of protein phosphatase 1 (PP1), is implicated in regulating hepatic glycogenesis and glucose homeostasis in a manner tightly orchestrated with the fasting–feeding cycle.


RESULTS

PPP1R3G in the liver is upregulated during fasting and downregulated after feeding. PPP1R3G associates with glycogen pellet, interacts with the catalytic subunit of PP1, and regulates glycogen synthase (GS) activity. Fasting glucose level is reduced when PPP1R3G is overexpressed in the liver. Hepatic knockdown of PPP1R3G reduces postprandial elevation of GS activity, decreases postprandial accumulation of liver glycogen, and decelerates postprandial clearance of blood glucose. Other glycogen-targeting regulatory subunits of PP1, such as PPP1R3B, PPP1R3C, and PPP1R3D, are downregulated by fasting and increased by feeding in the liver.


CONCLUSIONS

We propose that the opposite expression pattern of PPP1R3G versus other PP1 regulatory subunits comprise an intricate regulatory machinery to control hepatic glycogenesis during the fasting–feeding cycle. Because of its unique expression pattern, PPP1R3G plays a major role to control postprandial glucose homeostasis during the fasting–feeding transition via its regulation on liver glycogenesis.

Diabetes Journal publish ahead of print articles

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Eliminating the ‘Post’ Potential of Pre-Diabetes – New Nutritional Supplement Stabilizing Insulin Resistant Blood Sugars Before They Turn Into Full-Blown Diabetes




Houston, TX (PRWEB) December 3, 2008

Each year, more and more individuals are being slapped with a potentially serious medical diagnosis. They’re being told by their doctors that they are insulin resistant. Also referred to as pre-diabetes, if left unchecked, insulin resistance can quickly morph into full-blown diabetes, bringing with it all the life-threatening complications associated with that disease. The good news is that positive lifestyle alterations can halt pre-diabetes in its tracks. A new all-natural nutritional supplement, Melabic, is helping to pave the way in that cessation. To learn how to organically keep insulin resistance from progressing into diabetes, visit Melabic, the sugar stabilizer, online at http://www.melabic.com.

According to the most recent estimates released by the U.S. Department of Health and Human Services, pre-diabetes is becoming a frequently more common diagnosis in the United States. Indeed, “about 40 percent of U.S. adults ages 40 to 74 – or 41 million people–had pre-diabetes in 2000.” Even newer data “suggest that at least 54 million U.S. adults had pre-diabetes in 2002.” That figure represents nearly a 32 -percent increase in just a two-year span.

These prevalence statistics speak for themselves. Diabetes is well on its way to becoming a national epidemic if Americans don’t start taking control of their health. Proper diet and exercise can go a long way toward staving off diabetes, but in and of themselves, they’re often not enough. Over time, the insulin resistant’s blood sugar levels are prone to rise as their glucose control capability plummets. Eventually these important lab numbers creep into actual diabetes territory. By that time, medication and often insulin shots become necessary to keep the problem under control.

Melabic, the all-natural sugar stabilizer, offers a better – and safer – solution. Containing nine nutrients, each one hand-selected for its ability to rejuvenate the metabolic system, Melabic gets to the root cause of the diabetes problem and heals its consequences. With just one easy-to-swallow pill a day, insulin resistant individuals and pre-diabetics can preserve their kidney function, prevent blindness, eliminate the likelihood of amputation and eradicate risk factors for heart disease and stroke.

In fact, the product’s developer is so sure that Melabic can make its users’ bodies less resistant to insulin, and thereby reverse the first signs of diabetes, that she offers an unconditional guarantee on the product. Users of the Melabic nutritional supplement who do not witness a noticeable drop in their glucose readings can return the product within 90 days of purchase for a full refund.

For more information on how to naturally reverse your insulin resistance and pre-diabetes, contact Julia Hanf at juliahanf@gmail.com. To see the common-sense three-step Melabic system or to order the nutritional supplement, visit Melabic online at http://www.melabic.com/p/p.html.

Contact Information:

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juliahanf (at) gmail.com

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Watch girls with type 1 diabetes for signs of disturbed eating.(Behavioral Pediatrics): An article from: Pediatric News

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Citation Details
Title: Watch girls with type 1 diabetes for signs of disturbed eating.(Behavioral Pediatrics)
Author: Gale Reference

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Blood Glucose Monitoring

How blood glucose monitoring can control diabetes. Watch this and more health videos at: www.answerstv.com

Pavel Fort MD Ped Endo
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8 Weeks to Maximizing Diabetes Control: How to Improve Your Blood Sugar and Stay Healthy with Diabetes

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